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206 次 拉伸誘導(dǎo)的內(nèi)皮細(xì)胞單層損傷的相關(guān)研究 2025-6-10
Stretch-induced damage in endothelial monolayersKeywords: Aging; Cell mechanics; Endothelium; Mechanobiology; Senescence; Stretch.由于血流的脈動(dòng)性，包括流體剪切力、壓力和循環(huán)拉伸在
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243 次 視網(wǎng)膜神經(jīng)節(jié)細(xì)胞經(jīng)IL-12-SCGF-β串?dāng)_誘導(dǎo)干細(xì)胞衍生的神經(jīng)保護(hù)作用 2025-6-9
Retinal ganglion cells induce stem cell-derived neuroprotection via IL-12 to SCGF-β crosstalkKWS：Retinal ganglion cells；stem cell；neuroprotection；IL-12；SCGF-β；cross
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318 次 血管內(nèi)皮-間充質(zhì)串?dāng)_通過(guò) Notch 信號(hào)驅(qū)動(dòng)人成骨細(xì)胞的成骨分化 2025-6-4
Endothelial-mesenchymal crosstalk drives osteogenic differentiation of human osteoblasts through Notch signalingKeywords: Co-culture; Endothelial cells; Notch signaling; Osteoblast
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252 次 TRPV4 抑制劑和機(jī)械負(fù)荷對(duì)減輕炎癥的協(xié)同作用 2025-6-3
Synergetic role of TRPV4 inhibitor and mechanical loading on reducing inflammationKeywords: anti-inflammatory phenotype; inhibition, mechanical loading; macrophage polarization; mi
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302 次 I 類 PI3Ks 激活小梁網(wǎng)細(xì)胞中拉伸誘導(dǎo)的自噬 2025-5-27
Class I PI3Ks activate stretch-induced autophagy in trabecular meshwork cellsKeywords: Autophagy; Glaucoma; Mechanical stress; PI3K; Primary cilia; Trabecular meshwork.眼壓升高（IO
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236 次 內(nèi)皮 IGFBP6 抑制血管炎癥和動(dòng)脈粥樣硬化 2025-5-26
Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosisKWS：IGFBP6；vascular inflammation；atherosclerosis動(dòng)脈粥樣硬化通常發(fā)生在血流紊亂（DF）區(qū)域，例如動(dòng)脈分支或彎
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339 次 c-REL串?dāng)_TXNIP-p38與非經(jīng)典NF-κB通路協(xié)調(diào)紊亂血流區(qū)動(dòng)脈粥樣硬化 2025-5-20
Endothelial c-REL orchestrates atherosclerosis at regions of disturbed flow through crosstalk with TXNIP-p38 and non-canonical NF-κB pathwaysKWS：c-REL, Shear stress, Endothe
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444 次 探秘表觀遺傳的技術(shù)原理及適用場(chǎng)景介紹 2025-5-19
經(jīng)典遺傳學(xué)理論認(rèn)為，DNA堿基序列作為遺傳信息的載體可以將親代性狀遺傳給子代。近年來(lái)，隨著對(duì)染色質(zhì)和組蛋白的深入研究，表觀遺傳學(xué)逐漸興起。表觀遺傳是指在DNA序列不發(fā)生改變的前提下，基因
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256 次 動(dòng)脈粥樣硬化中血流誘導(dǎo)的內(nèi)皮細(xì)胞重編程 2025-5-19
Flow-induced reprogramming of endothelial cells in atherosclerosisSubject terms: Cell biology, Systems biology動(dòng)脈粥樣硬化是一種主要影響動(dòng)脈的多因素慢性炎癥性疾病。內(nèi)皮細(xì)胞功能障礙
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364 次 抑制劑CHIR-99021的作用機(jī)制及在干細(xì)胞與類器官研究中的作用 2025-5-14
CHIR-99021（Laduviglusib）是一種高特異性的糖原合成酶激酶-3（GSK-3）抑制劑，因其在干細(xì)胞研究、細(xì)胞分化調(diào)控以及疾病研究等領(lǐng)域的廣泛應(yīng)用而備受關(guān)注。它通過(guò)抑制GSK-3的活性，激活Wnt/&bet
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423 次 文章分享ChIP-seq：如何解開擬南芥復(fù)制應(yīng)激謎團(tuán)？ 2025-5-13
2023年7月，在《Molecular Plant》期刊上發(fā)表的一篇研究論文“Distinctive and complementary roles of E2F transcription factors during plant replication stress responses”，該
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325 次 E2F1誘導(dǎo)IL-6炎癥循環(huán)介導(dǎo)癌癥免疫，預(yù)測(cè)T細(xì)胞表型轉(zhuǎn)換和治療反應(yīng) 2025-5-13
E2F1-induced autocrine IL-6 inflammatory loop mediates cancer-immune crosstalk that predicts T cell phenotype switching and therapeutic responsivenessKeywords: CD4 +/CD8 + T cells;
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305 次 IL-33 經(jīng) OX40L 促進(jìn)人肥大細(xì)胞誘導(dǎo) CD4+ T 細(xì)胞產(chǎn)生 IL-9 2025-5-12
IL-33-primed human mast cells drive IL-9 production by CD4+ effector T cells in an OX40L-dependent mannerKeywords: IL-33; IL-9; OX40L; Th cell; mast cell.2 型免疫反應(yīng)是針對(duì)皮膚和粘
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339 次 運(yùn)動(dòng)減輕血流再循環(huán)激活代謝轉(zhuǎn)能器 SCD1 催化血管保護(hù)性代謝物 2025-5-7
Exercise mitigates flow recirculation and activates metabolic transducer SCD1 to catalyze vascular protective metabolitesKS：Exercise；flow recirculation；SCD1作為對(duì)周期性心臟收縮的
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330 次 靶向軟骨下骨骨細(xì)胞中的H19用于減輕骨關(guān)節(jié)炎軟骨降解 2025-5-6
Targeting Long Noncoding RNA H19 in Subchondral Bone Osteocytes and the Alleviation of Cartilage Degradation in OsteoarthritisKWS：LncRNA H19；Subchondral Bone Osteocytes；Cartilag
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381 次 內(nèi)皮雌激素-心肌cGMP軸決定壓力超負(fù)荷期間的血管生成和心臟功能 2025-4-28
Endothelial oestrogen-myocardial cyclic guanosine monophosphate axis critically determines angiogenesis and cardiac performance during pressure overloadKeywords: Angiogenesis; Cycl
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498 次 揭秘TH17細(xì)胞分化“開關(guān)”：ChIP-seq 技術(shù)破解基因調(diào)控密碼 2025-4-27
2017年發(fā)表在Nature上的“Reversing SKI–SMAD4-mediated suppression is essential for TH17 cell differentiation”的文章揭示了TGFβ的“反向調(diào)控”策略：正常
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392 次 機(jī)械拉伸誘導(dǎo)的活性氧驅(qū)動(dòng)新生豬腎上皮細(xì)胞內(nèi)皮素的產(chǎn)生 2025-4-27
Induction of reactive oxygen species by mechanical stretch drives endothelin production in neonatal pig renal epithelial cellsKeywords: Acute kidney injury; Endothelin; Endothelin
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407 次 Hes1/Piezo1 通路在糖皮質(zhì)激素誘導(dǎo)的骨質(zhì)疏松癥中的關(guān)鍵作用 2025-4-22
The pivotal role of the Hes1/Piezo1 pathway in the pathophysiology of glucocorticoid-induced osteoporosisKeywords: Bone biology; Bone disease; Osteoporosis; Therapeutics.糖皮質(zhì)激素
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409 次 大腦通過(guò) PGE2 骨內(nèi)感受調(diào)節(jié)負(fù)重骨：踝關(guān)節(jié)骨性關(guān)節(jié)炎和疼痛的影響 2025-4-21
Brain regulates weight bearing bone through PGE2 skeletal interoception: implication of ankle osteoarthritis and painSubject terms: Bone, Pathogenesis內(nèi)感受（Interoception）是一種監(jiān)
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